To Evaluate the Efficacy of a Low Dose of Ketamine in Attenuating Haemodynamic Stress Response Induced by Pneumoperitoneum in Laproscopic Cholecystectomy Under General Anaesthesia- A Prospective Study

Abstract

Background: Pneumoperitoneum affects homeostasis and leads to alterations in cardiovascular and pulmonary stress response during laproscopy. Various pharmacologic interventions have been tried to attenuate the response. N-methyl daspartate (NMDA) receptor antagonists like MgSO4 have received great attention. We conducted this study using low dose of ketamine in attenuating pressor response. Method: Patients who underwent laparoscopic cholecystectomy divided in group K (ketamine0.5 mg/kg)and group N(Normal saline). After induction of general anaesthesia but ten minutes before creation of pneumoperitoneum, the (group K) received ketamine 0.5 mg/kg diluted in normal saline intravenously where as group N received same amount of Normal saline. Haemodynamic parameters recorded and results observed. Results: Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure were significantly attenuated in group K(p<0.05) as compared to group N Conclusion: ketamine attenuates hemodynamic response in pneumoperitonium in laparoscopic cholecystectomy without changes in ETCO2.