Observational Study of the Effects of Inj. Etomidate as an Inducing Agent in Patients with Low Ejection Fraction for Non Cardiac Surgeries

Abstract

Introduction: Etomidate is a carboxylated imidazole derived nonbarbiturate & the most cardiostable inducing agent. However the adverse effects like myoclonus can be prevented by premedicating with fentanyl. Method: 50 Patients with ejection fraction 25%-50%, of ASA III and IV posted for non cardiac surgery were premedicated with inj. fentanyl IV. After preoxygenation, induction was done with etomidate 0.3 mg/kg IV over 60 seconds, followed by normal protocol. HR, BP, SpO2, pain on injection & myoclonus were monitored at the time of induction 60, 80, 100 and 120 secs after giving the drug. Result: There was no significant difference in HR & BP after induction with Etomidate with SD 83.576 ± 14.04, 120.2 ± 9.9 (systolic bp) respectively (p> 0.05) with no pain on injection and insignificant incidence of myoclonus (28 %) (p>0.05) Conclusion: Etomidate is a Cardioprotective drug with no pain on injection and least complications and side effects.