Correlation of Serum Uric Acid and Killip’s Class in Patients with Acute Myocardial Infarction

Abstract

Background: Acute myocardial infarction (AMI) is a form of ischemic heart disease (IHD) which has emerged as a major contributor to increase in morbidity and mortality. Various studies have found uric acid as a risk factor for cardiovascular disease and a negative prognostic marker for mortality of patients. Aim: To study if there is any correlation between serum uric acid levels and killips class in patients of acute myocardial infarction. Material and Methods: It was an observational study done for 2 years in a tertiary health care centre, in which 75 patients with AMI were included. Serum UA (Uric Acid) level was measured on day 0, 3 and 7 with uricase method and a detailed history in realtion to killips class was taken. The data collected was analysed to see the pattern of elevation of serum uric acid level and compare it with killips class of patients on days 0,3 and 7. Results: We observed that serum uric acid levels were elevated in patients with acute MI and the levels were almost same on days 0, 3and 7. Patients who had higher killips class also had higher SUA levels. Almost all patients who expired had SUA > 7. Conclusion: Our study strengthens the previous reports that, serum uric acid could be marker for predicting acute MI-related prognosis and the combination of Killip’s class and serum UA level after acute MI could a good predictor of mortality in patients who have acute MI.