To Investigate Effect of Some Hepatoprotectiveagents on Drug Induced Hepatotoxicity in Albino Rats

Abstract

Introduction: Drug induced hepatotoxicity is a potential adverse effect, contributing to the health burden, with several mechanisms involved in causing liver injury. Many drugs and ingested substances cause the problem, with few drugs available for the treatment. Hence, we aimed to evaluate the hepatoprotective effect of certain hepatoprotective agents. Material and Methods: Diclofenac (72, 96 & 240 mg/kg) was administered orally to evaluate its per se effect. Further, DL-Methionine (700 & 1400 mg/kg) and NAcetylcysteine (450 mg/kg), were also evaluated for per se effect, followed by evaluation of their hepatoprotective effect against the Diclofenac-induced hepatotoxicity (96 & 240 mg/Kg, single oral dose) in the albino rats. Observations and Results: Diclofenac (96 & 240 mg/kg, single oral dose) per se, was found to be hepatotoxic, while DL-Methionine (700 &1400 mg/kg), and NAcetylcysteine (450 mg/kg) though altered the liver enzymes levels it was not significant, hence they were found not to be hepatotoxic. Both DL-Methionine and N-Acetylcysteine in above doses significantly protected the animals against the Diclofenac-induced hepatotoxicity. However, no statistical difference was found between the hepatoprotective effect of DL-Methionine and NAcetylcysteine. Conclusion: Both DL-Methionine and N-Acetylcysteine have been hepatoprotective against the Diclofenac-induced Hepatotoxicity