Cd (II) Complex of Some Novel 5-Nitroimidazole Derivatives: Synthesis, Characterization and Antibacterial Activity

Abstract

Bacterial resistance development to the existing drugs has encouraged the search for novel targets. The novel metal complexes and their derivatives may represent an interesting approach for designing new antibacterial drugs. This may be due to the dual mechanism of both ligands and metal ion interacting in different stages of life cycle of bacteria.The aim of the present work was to synthesize a novel series of Cd (II) complexes of 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1-substitutedethanone and evaluate their in-vitro antibacterial activity. Methods: The metal-ligand complexes of cadmium have been synthesized in good yield. Synthesized complexes were evaluated in-vitro for their antibacterial activity by agar well diffusion method. Results: All the synthesized compounds were characterized by IR, 1H NMR, mass spectra and molar conductance. Some of the metal complexes were found to be moderately active against Gram-positive bacteria, B. pumilus ATCC 14884 and S. aureus ATCC 29737. Conclusion: Cd (II) complexes of 2-(1-substituted-5-nitro-1Himidazol- 2-yl)-1-substitutedethanone have been synthesized and characterized. The synthesized complexes show inhibitory activity against only Gram-positive bacteria.