Synthesis and Evaluation of Some Five Member Heterocyclic Compounds

Abstract

The nitroheterocyclic compounds have proved to be very effective antimicrobial agents and very valuable member of limited armamentarium of antiprotozoal agents. The mechanism of action of nitroheterocyclic agents depend solely upon the reduction of the nitro group to toxic radicals and binding to the protein and DNA. The two families of nitroheterocyclic; the nitroimidazole and nitrofurans are very different in their reduction characteristics. Drug resistance to the nitroheterocyclic drugs and cross resistance leads to the development of new derivatives. A number of 5-nitoimidazole with substitution at 2nd position of 5-nitroimidazole with various substituents like beta lactam ring, dioxane, 2-hexahyropyrimidine, 1-formyl and 2-formyl ring, pyridinium, tetrahyropyridine derivatives and nitroimidazole with a trisubstituted ethylenic double bond are reported recently. Such studies indicate the thrust for the future development of new nitroimidazole drugs. In the present study the 5- nitroimidazoles like tinidazole and dimetridazole molecule is thought to be modified at 2nd position.