Synthesis and Pharmacological Evaluation of Some Substituted Coumarin Derivatives

Abstract

Inflammation occurs as a defensive response, which induces physiological adaptations to limit tissue damage and remove the pathogenic infections. Diseases caused by inflammation are an important factor of morbidity and mortality in humans. It is a fundamental pathologic process consisting of a dynamic complex of cytological and chemical reactions that occur in the affected blood vessels and adjacent tissues (connective tissues), in response to an injury or abnormal stimulation caused by a physical chemical or biological agents resulting in; (i) The local reactions and resulting morphologic changes. (ii) The destruction or removal of the injurious material. (iii) The responses that lead to repair and healing. The so called “cardinal signs” of rubor (redness) calor (heat), tumor (swelling) dolor (pain). Platelets provide the initial haemostatic plug at sites of vascular injury. They also participate in reaction that leads to atherosclerosis and pathological thrombosis in numerous animal studies. Antagonists of platelet function have thus been used in attempts to prevent thrombosis and to alter the natural history of atherosclerotic vascular disease. As one of the cyclooxygenase product is thromboxane A2. Ryn reported aspirin as dual inhibitor as it block production of thromboxane A2 by covalently acetylating a serine residue near the active site of cyclooxygenase, it is used as antiplatelet agent.