Comparative Study of Levosimendan Versus Dobutamine in View Difference in Mean Heart Rate , Sbp & Dbp Between Two Groups in Patients Operated for Cardiacsurgery Patients in Tertiary Care Hospital

Abstract

Introduction:- Cardiopulmonary bypass is associated with clinically asymptomatic to clinically symptomatic myocardial injury . Oxygen & ATP deprivation and/or reperfusion injury following cross clamp removal are associated with myocardial insult. Levosimendan has also been used in this context but only in a small number of patients so the clinical-experience is very limited. So we studied a comparison between levosemendan and dobutamine in on-pump surgery patients. Methods:- 60 patients posted for CABG in cardiac on pump surgeries. They were allocated randomly to two equal groups (Group L - inj. levosimendan 12μg/kg over 10 minutes after cross clamp removal and 0.1μg/kg/min started after that andinj.Dobutamine 5 μg/kg/min infusion at the time of weaning from cardiopulmonary bypass) from feb 2014 to july 2015 at dheeraj general hospital piparia Vadodara.. Results:- In our study we found there was statistically significant difference in mean heart rate between two groups (p˂0.001).Heart rate increased more in the levosimendan group than in the dobutamine group. there is no statistically significant difference in systolic and diastolic blood pressure in both groups(p>0.05). Conclusion:-Levosemendan is better than dobutamine in maintaining hemodynamic stability during intraoperative and postoperative period of patients coronary artery bypass graft going for on-pump surgery