Review on Liquisolid Compacts: A Novel Approach to Enhance Solubility of Poorly Soluble Drugs

Abstract

A “Liquisolid” technique is a novel & capable addition towards such an aims for solubility enhancement & dissolution improvement, areby it increases a bioavailability. It contains liquid medications in powdered form. This technique is an efficient method for formulating water insoluble & water soluble drugs. This technique is based upon a admixture of drug loaded solutions with appropriate carrier & coating materials. A use of non-volatile solvent causes improved wettability & ensures molecular dispersion of drug in a formulation & leads to enhance solubility. By using hydrophobic carriers (non-volatile solvents) one can modify release (sustained release) of drugs by this technique. Liquisolid system is characterized by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro release & in-vivo evaluation. By using this technique, solubility & dissolution rate can be improved, sustained drug delivery systems be developed for a water soluble drugs.