Observational Study to Compare Intraoperative Haemodynamics and Recovery Profile with Desflurane and Sevoflurane in High Risk Patients Receiving General Anaesthesia

Abstract

AIMS AND OBJECTIVES: Comparison of desflurane and sevoflurane for intraoperative hemodynamics and postoperative recovery. MATERIAL AND METHODS: Sixty patients classified in ASA III , IV posted for major surgeries lasting for more than two hours randomly assigned to receive sevoflurane or desflurane in general anesthesia. After premedication all patients received inj. fentanyl , induces with inj. propofol and scholine, intubated and maintained on oxygen/nitrogen (50%/50%) with intermittent atracurium. Both group received FGF 4 lit/min for first 10 mins. with desflurane (3-4%) in group I and sevoflurane (2-3%) in group II. After 10 mins. FGF was reduced to 2 lit/min. with inhalational gases adjusted to maintain hemodynamic parameter within 20% of baseline values or according to clinical signs. Inhalational anesthetics were discontinued immediately after closure . Patients were reversed. The times for discontinuation of inhaled anesthetics to spontaneous eye opening , obeying verbal commands , recal of name and orientation of time and place every 2 mins were measured. In post anesthesia care unit aldrete’s score was recorded every 15 mins. till a score of 9 was achieved. Hemodynamics measured every 2 mins prior to skin incision and every 10 mins there after. RESULTS AND SUMMARY: Intraoperative hemodynamics did not differ between the two groups. The time to response to spontaneous eye opening , obeying verbal commands , recal of name and orientation to time and place was shorter after desflurane,however aldrete score was similar. CONCLUSION: Desflurane and sevoflurane produce similar hemodynamic changes but immediate recovery was significantly faster after desflurane.