Formulation and Development of Floating Microsphere of Clarithromycin

Abstract

The objective of the study was to develop a stomach-specific drug delivery system for controlled release of clarithromycin. Microspheres of clarithromycin were prepared by emulsification-solvent evaporation method using ethylcellulose as matrix polymer and Carbopol as polymer. The prepared microspheres were subjected to evaluation for particle size, incorporation efficiency, in vitro buoyancy and in vitro drug release characteristics. Floating microspheres of Clarithromycin could localize the drug within the peptic region to enhance the drug absorption process in a site specific manner. Developed floating system of Clarithromycin increase the local drug concentration by prolonging the residence time of the formulation in the stomach. The developed formulations will be meet all the pre-requisites to floating system, gelled and floated instantaneously at the pH conditions of the stomach.