Formulation and Evaluation of Leflunomide Loaded Magnetic Solid-Lipid Nanoparticles for The Targeted Therapy of Breast Cancer

Abstract

The present research work focuses on the targeted delivery of anti-cancer drug Leflunomide. This drug belongs to BCS class II which implies that it has lipophilic nature with poor water solubility. Hence an attempt was made to reduce the particle size to nano dimensions using microemulsion technique. In this technique, stearic acid was used as the lipid and tween 80 was used as a surfactant. For the tumor targeted formulation, the Magnetic nanoparticle was prepared using precipitation technique. The Solid Lipid Nanoparticles was coated on the Magnetic Nanoparticles. The resultant nanoparticles were optimized using 3² full factorial design and characterized for their entrapment efficiency, percentage yield, in-vitro diffusion studies. The particle size and zeta potential were found out and surface morphology was studied using Scanning electron microscopy. The histopathology study clearly showed a significant concentration of iron in test (magnetically targeted) kidney compared to control kidney.