An Approaches and Patents on Controlled Release Gastroretentive Drug Delivery System – A Review

Abstract

Oral drug delivery of drugs is by far the most preferable route of the delivery due to the ease of administration, patient compliance, and flexibility in the formulations but besides they also have the drawbacks of non-site specific and short gastric residence time. To overcome the drawbacks of the conventional oral drug delivery systems, several technical advancements have led to the development of Gastroretentive drug delivery system (GRDDS) that could revolutionize the method of medication and provide many therapeutic benefits. Thus, Gastroretentive drug delivery systems are a good example as they enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract (GIT) and/or to promote local activity in stomach and duodenum. Several approaches are used to increase the gastric retention time. The review highlights the various pharmaceutical approaches for gastro retention such as floating drug delivery systems, muco/bio adhesive, high-density systems, expandable systems, super porous hydrogels systems, magnetic systems, ion-exchange resin systems and recent patents filed or granted for these approaches.