Synthesis and Analysis of Novel Triazolo Thiadiazole Derivatives as a Biological Interest

Abstract

Heterocyclic compounds are highly attracted to medical chemicals due to their unique chemical properties and wide range of biological activity. Triazolo-thiadiazole and related fused heterocyclic compounds are of interest as potential bioactive molecules.Triazolothiadiazole extracts are highly sensitive to organic chemicals due to their biological and chemotherapeutic value.Research in the field of antimycobacterium, anti-inflammatory and anti-microbial therapy is continuous ongoing and demanding study. Hence, the search for newer effective anti-mycobacterium, anti-inflammatory and antimicrobial agent is imperative. The need of new anti-microbial, anti-mycobacterial agents is justified because more microorganisms are being resistant to the present drugs available in the market. Worldwide researchers are trying to synthesize new drugs with better pharmacokinetic and dynamic properties with less adverse effects.The literature survey suggests that the fuse ring of Triazolo-thiadiazole derivatives have proved to be good bioactive molecules. They have shown diverse biological activities like anti-bacterial, anti-fungal, anti-inflammatory, anti-tubercular, anticancer, anticonvulsant, antioxidant, analgesic, etc.Therefore, in view of above facts it was thought of interest to synthesize some Triazolo-thiadiazole derivatives. Triazolo-thiadiazole has played a crucial role in the history of chemistry. Owing to their versatile chemotherapeutics importance, significant research efforts have been made on these nuclei. The literature review suggested that Triazolo-thiadiazole possesses wide and potent activity as an antibacterial, anti-inflammatory, anti-diabetics, and anti-tubercular agent.Hence, there is a need to develop an efficient and yieldoriented process for the preparation of such derivatives.