Formulation and Evaluation of Fast Dissolving Film of Methylcobalamin

Abstract

Over the past decade, there has been increasing interest in using sublingual route of administration. Which directly inject the dug in to the blood stream. So for drugs having less bioavailability it can be helpful to increase absorption. Also it quits the first past metabolism. Therefore drug like methylcobalamine which is having very less bioavailability when given by this route will lead to increase the absorption and at last the bioavailability. Hear by using polymers like PVA and PVP in a combination with penetration enhancer like SLS and PEG 400 as plasticizer we had prepared fast dissolving sublingual film. The result itself shows increase in the absorption (penetration) of methylcobalamine much more than given by the GI tract. Our work demonstrates that the obtained fast dissolving sublingual film of methylcobalamin can be used for the patient.