Solubility Enhancement Techniques as a Strategy to Improve the Solubility of Lornoxicam

Abstract

Lornoxicam is a BCS class- II non-steroidal anti-inflammatory drug (NSAID) of oxicam class that exhibits analgesic, anti-pyretic and anti-inflammatory activities. The aim of study was to enhance the solubility of lornoxicam using different solubility enhancement techniques. Three approaches viz; hydrotropy, cosolvency and mixed solvency techniques were carried out to enhance the solubility of lornoxicam. Many hydrotropes like sodium acetate, sodium salicylate, sodium ascorbate, sodium citrate, sodium benzoate, urea and nicotinamide in different molar concentration and cosolvents like polyethylene glycol (PEG), propylene glycol and glycerin in different percentage were used to enhance the solubility of poorly soluble drug. In addition to that, a mixed solvency technique was also adopted to study maximum solubility of drug. A 7.25 fold and 26 fold increase in solubility of drug was observed compared to water by using 2M nicotinamide and 40% PEG 600, respectively. Similarly, A 358 fold solubility enhancement was obtained with mixed solvency technique using mixture of 10% sodium citrate, 10% sodium benzoate, 10% nicotinamide, 5% PEG 600, 5% PEG 400 and 5% propylene glycol. The study concluded that suitable solvent system can be developed using hydrotropy, cosolvency or mixed solvency techniques for BCS class- II category drug like lornoxicam to design suitable liquid dosage form