Histological and Histopathological study of Cholecystectomy Specimens

Abstract

Introduction: Cholecystectomy specimen (gallbladder) is the frequently encountered surgical specimen in a histology laboratory. It shows different histopathological changes ranging from inflammation to pre malignant changes to carcinoma. Incidental detection of gallbladder cancer in cholecystectomy specimen has been reported in 0.3 to 2% of all cholecystectomies performed for benign condition. Aims: To study the different histopathological entities of the cholecystectomy specimens and to find out the frequency of gallbladder cancer in these specimens, determine the gender and age wise distribution of the patients, find out the association of gallstones with different gall bladder lesions, and obtain clinic-pathological correlation of various gall bladder lesions. Material & Methods: The histopathological study was carried out on 100 cholecystectomy specimens received in the Department of Pathology, Dhiraj Hospital, Waghodia, during the study period of two years. Results: Age of patients in the study group ranged from 8-81 years with mean age of 44.5 years. Out of total 100 cases, 22 (22%) were male and 78 (78%) were female patients with male : female ratio being 1:3.5. Out of 100 cases studied, only 4 were proved to be neoplastic; with all being adenocarcinoma. Conclusion: In the present study, 100 cases of holecystectomy specimens were studied for histopathological evaluation showing various gallbladder lesions like chronic cholecystitis, acute cholecystitis, cholelithiasis, xanthogranulomatous cholecystitis, adenomyomatosis, metaplasia and carcinoma.