Comparision of the Efficacy of Ibuprofen to Ibuprofen, Paracetamol and Caffeine Combination in the Control of Postoperative Pain after Periodontal Surgery- A Split Mouth Cross-Over Study”

Abstract

Introduction: The present split mouth cross over study was conducted with an objective to compare combination of Ibuprofen 400 mg, Paracetamol 325mg and Caffeine 25mg (test) to Ibuprofen 400mg (control) in pain management after periodontal surgeries. Method: 25 patients were prescribed test drug after first flap surgery and then control drug after next surgery at a cross-over a period of 3 weeks. Patients were asked to maintain pain chart measuring Numerical Rating Scale (NRS-10) for first 8 hours after surgery, on day 1, 2 and 3 after surgery. Result: Pain scale ratings are significantly less at different timelines for test group as compared to control group (P=0.000). Conclusion: This study showed that the combination drug has better efficacy for pain management as compared to ibuprofen alone and with minimal adverse effects. This combination drug can be routinely prescribed routinely for pain management after periodontal surgery.