To Evaluate the Efficacy of Low Dose Ketamine in Attenuating Haemodynamic Stress Response Induced by Pneumoperitoneum in Laparoscopic Cholecystectomy Under General Anaesthesia: A Prospective Study

Abstract

Background: Pneumoperitoneum required for laparoscopy causes cardiovascular and pulmonary stress responses. Various pharmacological interventions have been used to attenuate those sympathetic response. N-methyl-D-aspartate(NMDA) receptor antagonists like ketamine have received great attention. We used low dose of ketamine 0.3mg/kg for attenuation of pressor response. Method: Patients scheduled for laparoscopic cholecystectomy were divided in group K (ketamine0.3 mg/kg)and group N(normal saline).Ten minutes before creation of pneumoperitoneum, the (group K) received ketamine 0.3 mg/kg diluted in normal saline intravenously whereas group N received same amount of normal saline. Hemodynamicparameters were monitored and results observed. Results: Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure were significantly attenuated in group K (p<0.001) as compared to group N. Conclusion: Low dose ketamine attenuates hemodynamic response in pneumoperitonium in laparoscopic cholecystectomy. Background: Pneumoperitoneum required for laparoscopy causes cardiovascular and pulmonary stress responses. Various pharmacological interventions have been used to attenuate those sympathetic response. N-methyl-D-aspartate(NMDA) receptor antagonists like ketamine have received great attention. We used low dose of ketamine 0.3mg/kg for attenuation of pressor response. Method: Patients scheduled for laparoscopic cholecystectomy were divided in group K (ketamine0.3 mg/kg)and group N(normal saline).Ten minutes before creation of pneumoperitoneum, the (group K) received ketamine 0.3 mg/kg diluted in normal saline intravenously whereas group N received same amount of normal saline. Hemodynamicparameters were monitored and results observed. Results: Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure were significantly attenuated in group K (p<0.001) as compared to group N. Conclusion: Low dose ketamine attenuates hemodynamic response in pneumoperitonium in laparoscopic cholecystectomy.