Observation Study to Compare the Effects of Etomidate and Propofol for Induction in General Anaesthesia in Patients with Cardic Disease

Abstract

Aim :To observe the effect of inj etomidate 0.3 mg/kg and inj propofol 2.5mg/kg during induction in patients with cardiac disease for non cardiac surgery in view of hemodynamic parameters, pain on injection, myoclonus and other side effects. Methods: 60 Patients randomly divided in 2 groups, P and E, for propofol and etomidate 30 each of ASA III,IV. Premedicated with glycopyrrolate ,ondensetron and fentanyl.Induced with propofol or etomidate over 60 secs, maintained with O2, N2O, inhalation agent and muscle relaxant. Heart rate and blood pressure recorded at preinduction, 0secs, 60 secs, 80 secs,100secs and120 secs.Pain on injection and myoclonus compared according to grades assigned. Results: Heart rate and blood pressure were more stable with less pain on injection with etomidate. Myoclonus was less with propofol. Conclusion: Etomidate is hemodynamically stable with less pain on injection and high incidence of myoclonus than propofol.