Comparative Effectiveness of Rocuronium Versus Vecuronium on Onset Time for Intubation, Intubation Conditions and Duration of Action: A Randomized, Controlled Study on Patients Undergoing General Anesthesia.

Abstract

Background and Aim: Due to paucity of data, we compared onset time, intubation conditions and duration of action of Rocuronium versus Vecuronium. Methods: 60 patients matching study inclusion were randomly divided in group R(rocuronium, n=30) or V(Vecuronium, n=30).Onset times, scale of intubating conditions and duration of action were measured in both groups and compared. We also assessed hemodynamic responses post induction in both groups. Results: Out of total 60 patients, group R showed lesser time taken for intubation ie. within 60 and 90 secs only as compared to group V(i.e. extended upto 120 and 150 sec). In group R, intubating conditions were excellent in 24 patients (80%) whereas 11 patients (36.6%) in group V. In both groups, hemodynamic difference was statistically non-significant. Conclusion: Considering proven superiority for desired clinical outcomes, rocuronium could be a considerable option for neuromuscular blockade.