Acute Diffuse Digital Gangrene- A Rare Initial Manifestation of Mixed Connective Tissue Disorder (MCTD).

Abstract

Introduction: Mixed connective tissue disorder (MCTD), unlike other connective tissue disorders have a milder course. MTCD with only digital gangrene without organ damage, as an initial presentation is rare. Case Report : A young female presented with c/o fever and blackish discoloration of all toes and fingers (toes > fingers). All her major organ functions were normal. Her CRP was raised and U1 snRNP antibody was positive. She responded well to injectable steroids. Conclusion: This patient with presentation of diffuse digital gangrene was diagnosed with MTCD, without major organ involvement and showed good recovery with steroids. So MCTD is a reversible cause of digital gangrene and should be considered in young females without risk factors of developing gangrene.