An Observational Study of Pregabalin 150 Mg 300 Mg for Post- Operative Analgesia in Lower Limb Orthopaedic Surgeries under Spinal Anaesthesia

Abstract

INTRODUCTION : Pregabalin is a synthetic molecule , a structural derivative of the inhibitory neurotransmitter gamma- amino butyric acid ( GABA) . It is an α- 2-δ ligand having analgesic , anti- convulsant, anxiolytic properties, binding to α- 2-δ subunits of the calcium channels resulting in a decrease in neurotransmitters including glutamate, serotonin . Pregabalin is associated with few dose dependent side effects , sedation being the most common one. METHODS: Sixty patients undergoing lower limb orthopaedic surgeries were randomized to receive tablet pregabalin 150 mg and pregabalin 300 mg ( 30 each) one hour before surgery. Intra-operative haemodynamics, post- operative analgesia and adverse effects were compared. RESULTS: Both groups were comparable in terms of Intra-operative haemodynamics, post- operative analgesia and adverse effects . CONCLUSION: Group receiving pregabalin 300 mg had better post- operative analgesia , required fewer doses of rescue analgesia with mild sedation which is clinically non- significant.