Diagnostic Value of CD-10 Marker in Differentiation of Malignant Thyroid Carcinoma from Benign Thyroid Lesion

Abstract

Introduction: Thyroid cancer is considered as,the most common endocrine malignancy. PTC (Papillary Thyroid Carcinoma) is the most common form of malignant thyroid tumor. This study was aimed to study the expression and sensitivity of ,immunohistochemical marker CD 10 for papillary thyroid carcinoma and benign thyroid lesion. Methods: The present study,was carried out in the Department of Pathology, Dhiraj General Hospital & Srimati Bhikhiben Kanjibhai Shah Medical Institute & Research Centre, Sumandeep Vidyapeeth, Piparia. A total of 30 cases of thyroid lesion in which 10 are papillary thyroid carcinoma and 20 are benign follicular adenoma were evaluated after its histological diagnosis with immunohistochemical marker CD 10. Results: From selected 30 cases studied in two groups of PTC (n = 10) and follicular adenoma (n = 20), CD10 was immunohistochemically expressed in 20% of PTC cases, but in none of the follicular adenoma (0%). There was not significant relationship between expression of CD10 with the type of thyroid lesion, age and sex of the studied population (P > 0.05). Conclusions: The result of present study concluded that, the overall sensitivity of CD 10 marker for detecting PTC is too less to recommend its use in daily practice. To find out the diagnostic usefulness of CD 10, further studies including larger sample size with adequate number of controls (adenomas) will have to be done.