An Observational Study to Compare the Effect of Two Different Doses of Dexmedetomidine on Haemodynamic Response to Laryngoscopy and Endotracheal Intubation

Abstract

Introduction The hemodynamic response to laryngoscopy and endotracheal intubation has been recognized since long. These changes in the form of tachycardia, hypertension and arrhythmia may be potentially dangerous. So, the aim of the study was to compare dexmedetomidine1μg/kgand dexmedetomidine 0.5μg/kg for control of hemodynamic changes during endotracheal intubation. Material and Methods In this observational study, 60 patients scheduled for elective surgeries under general anaesthesia were divided into two groups Group D1(Inj. Dexmedetomidine dose 1μg/kg iv) and Group D0.5(Inj. Dexmedetomidine dose 0.5μg/kg iv). Patients belonging to ASA I & ASA II of both sexes, aged 20-60 years, were included in this observational study. Heart rate, blood pressure, ECG were monitored continuously and recorded before giving the study drug, after giving the study drug, at intubation then at1,3,5, 10 minutes after intubation. Data were analysed and p<0.05 was considered significant. Result:Dexmedetomidine group D1 had 4.70% rise in heart rate at time of intubation and group D0.5 had 9.59% rise which was statistically significant(p<0.05). Except during intubation difference in heart rate between two groups was statistically insignificant.(p>0.05) Group D0.5 had significant rise in SBP and DBP during intubation compared to Group D1.Maximum rise in SBP and DBP in Group D0.5 was 14.53% and 12.84% XI respectively, whereas in Group D1 it was 5.55% and 8.90% respectively. In Group D0.5, rise in BP lasted longer after intubation compared to Group D1. There was no significant difference in average thiopentone dose used for induction in both groups. (p>0.05) No side effects of the drug were seen during the study period. Conclusion: Dexmedetomidine at a dose of 1μg/kg significantly attenuated the sympathetic response of laryngoscopy and intubation whereas dose of 0.5μg/kgalso reduced the pressure response, but its effect was less than that of1μg/kg.